Table 1 details other syndromes associated with hypogonadism. Males with primary hypogonadism (most commonly due to disorders affecting the testes) will have low testosterone with high LH and, F.S.H.; while males with secondary hypogonadism (most commonly due to disorders affecting the hypothalamus or anterior pituitary) will have low testosterone levels with low or normal LH and FSH [15] (Table 1). This evidence concerns the gene PLOD1 and hypogonadotropic hypogonadism.