These include genetic hypertension (e.g., spontaneously hypertensive rats [SHR]) [123,124], AngII-induced hypertension [124], renal models of hypertension [125,126], DOCA salt hypertension [127], programmed hypertension [128] and diet-induced metabolic syndromes [129,130,131]. The gene discussed is AGT; the disease is hypertensive disorder.