Regarding the impact of insulin levels on diet-induced prostate cancer growth, one study involving LAPC-4 xenografts in SCID mice receiving three different diets, NCKD (84% fat), 10% carbohydrate diet (74% fat), or 20% carbohydrate diet (64% fat), proposed that mice receiving a 10% carbohydrate diet had larger tumors than the other groups despite mice receiving a 20% carbohydrate diet having the lowest insulin levels [28]. This evidence concerns the gene INS and Familial prostate cancer.