IGFBP1 and Familial prostate cancer: Kobayashi et al. showed that an LFD reduced the development of prostate cancer in Hi-Myc mouse transgenic model with the suppression of the IGF-AKT pathway, which leads to higher serum IGFBP-1 levels, reduced serum mitogenicity, and lower AKT, GSK3beta, and S6K activities [19].