IGFBP1 and neoplasm: The same group showed that LFD-fed mice had significantly slower tumor growth rates, lower levels of serum insulin, tumor IGF-I mRNA expression, and tumor IGFBP-2 immunostaining, and higher levels of serum IGFBP-1, which indicated that IGF-I signaling modulated fat-induced tumor growth in LAPC-4 xenografts [15].