PTEN and acute promyelocytic leukemia: Chen et al. showed that among mice with Pten deletion and a double deletion of Pten and Promyelocytic Leukemia (PML), a suppressor of pp1α-dependent activation of MAPK signaling, those receiving a lard-based HFD displayed lymph node metastasis and lung metastasis, whereas those receiving a chow diet exhibited limited metastases [56].