PTEN and cancer: Kalaany et al. showed that 40% dietary restriction did not have any detectable effect on the extent or histological appearance of the PIN in Probasin-Cre; PTEN L/L prostate cancer models but significantly reduced tumor nodules in the lungs of K-RASLA2; P53 LSL/WT lung adenocarcinoma models [23], suggesting that the Phosphoinositide 3-kinase (PI3K)/ protein kinase B (AKT) pathway is critical for diet-induced cancer progression.