NPM1 and neoplasm: In a microarray-based approach, Matsuyama et al. revealed an NPM-ALK-STAT3-miR-135b axis, strongly polarizing T-cell differentiation toward the IL-17 producing immunophenotype through the suppression of the Th2 master regulators STAT6 and GATA3 [68], leading to the development of a pro-inflammatory tumor microenvironment.