Faslpr/lpr mice exhibited elevated levels of serum anti-dsDNA, whereas the Sh3bp2 gain-of-function mutation significantly suppressed serum anti-dsDNA levels in lupus-prone mice at 32 and 48 weeks (Figure 3a), indicating that the Sh3bp2 gain-of-function mutation negatively regulated autoantibody production in concert with the improved survival rate (Figure 1d). This evidence concerns the gene SH3BP2 and systemic lupus erythematosus.