Abnormal expression of monocyte-surface markers, such as FcγRIII, CD40, CD244, CR4, Siglec-1, and Siglec-4, have been reported in monocytes from patients with SLE [62,64,65,66]; therefore, dysregulation of monocyte surface molecules could skew optimal immune responses, including pathogenic cytokine and chemokine expression [62]. The gene discussed is CD40; the disease is systemic lupus erythematosus.