Germline DNA was only available for PCC6 and showed the SDHD variant in a heterozygous fashion, indicating loss of the wild type (WT) SDHD allele in the tumor (Figure 2), which was also confirmed by the loss of heterozygosity analyses for microsatellite markers flanking the SDHD gene (Figure 1B). This evidence concerns the gene SDHD and neoplasm.