RPS6KB1 and ovarian carcinoma: We confirmed these results, noting significant downregulation of p-AKT, p-ERK, p-mTOR, p-ULK1, p-P70S6K (Figure 2C) in A2780 ovarian cancer cells following both amino acid deprivation as well as complete serum starvation (HBSS supplemented with 3% glucose) at 2–4 h.