PPARGC1A and breast cancer: In fact, some evidence revealed that non-metastatic breast cancer proliferating cells satisfy their metabolic needs primarily through glycolysis [30], while in invasive metastatic breast cancer cells, mitochondrial respiration is induced to increase ATP levels through a mechanism associated with the overexpression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), which mediates mitochondrial biogenesis [31].