It should be noted, however, that an important clinico-genetic overlap may exist, as was demonstrated by a case report of Vanakker et al. [58] describing a patient in which signs and symptoms of both PXE and PXE-like syndrome were observed together with two ABCC6 mutations and a gain-of-function SNP in the GGCX gene, supporting the hypothesis that PXE-like syndrome is part of a wider spectrum of ectopic calcification disorders related to PXE. This evidence concerns the gene ABCC6 and Pseudoxanthoma elasticum.