In a study by Wang et al. [81], vitamin K2 was found to suppress the expression of Toll-like receptors 2 and 4 (TLR2–TLR4) in Apoe−/− mice, resulting in a significant reduction of atherosclerotic plaque formation and aortic intima calcification compared to Apoe−/− mice in the control group (who developed the typical vascular phenotype of extensive atherosclerosis with associated intima calcification). The gene discussed is APOE; the disease is atherosclerosis.