miR-1 and miR-133 affect the ryanodine-receptor-2 (RyR2) through their action on B56α and PP2A, which results in RyR2 hyperphosphorylation, increasing the spontaneous Ca2+ spark frequency and ventricular arrhythmia risk [48]. This evidence concerns the gene PPP2R5A and Ventricular arrhythmia.