Western blotting was performed to assess changes in the expression of cdk1/stat3-related molecules in the SMMC-7721 cells transfected with either control vector or shRNA HAMP. The results showed that after knockdown of the HAMP expression in SMMC-7721 cells and tumor tissues, the expression of cyclin-dependent kinases 1(cdc2) was significantly increased, and the expressions of stat3 and phospho-stat3 were significantly increased (Figure 6C,D), respectively. Here, HAMP is linked to neoplasm.