SHANK3 and autism spectrum disorder: SHANK3 (SH3 and multiple ankyrin repeat domains 3, also known as proline-rich synapse-associated protein 2 (ProSAP2)) is a known scaffolding protein of the postsynaptic density (PSD) of glutamatergic excitatory synapses [1,2,3] that has been associated with autism spectrum disorders (ASD) [4,5,6,7].