Recent findings from Mauro et al. also correlate with these data; indeed, they found that in MDA-MB-231 xenograft models the pre-treatment with adiponectin (1, 5 and 30 μg/mL) reduced tumor growth at all doses tested amplifying AMPK signaling and reducing cyclin D1 expression [139,141]. The gene discussed is CCND1; the disease is neoplasm.