In addition, it has been demonstrated that 25 μg/mL adiponectin reduced estrogen receptor alpha (ERα), insulin growth factor 1 receptor (IGF1R), progesterone receptor (PR) mRNA, and protein expression, suggesting the functional interaction between such receptors and adiponectin signaling in epithelial ovarian cancer cells [109]. The gene discussed is PGR; the disease is ovarian carcinoma.