Activation of K-Ras, a potent oncogene that drives the development of multiple cancers [75], in transformed skin cells resulted in production of IL-1α, which signals in an autocrine manner through IL-1R/MyD88/NF-κB pathway to synergize with K-Ras for the oncogenic progression of skin cancer [70]. This evidence concerns the gene NFKB1 and skin neoplasm.