PAX8 and serous adenocarcinoma: We initially surveyed PAX8 levels in a diverse array of cell lines (Figure 3A), and chose to use KURAMOCHI as the model system because it expressed abundant PAX8 and represented archetypal high-grade serous carcinoma (Domcke et al., 2013), the most prevalent and lethal histotype of ovarian cancer (Matulonis et al., 2016).