VEGFA and neoplasm: In addition, fibrinogen can bind some growth factors, such as vascular endothelial growth factor and contribute to the angiogenesis of tumor tissues that leads to tumor growth and metastasis.26, 27 Third, as a multiple integrin and nonintegrin receptors in tumor cells, fibrinogen can mediate cellular interactions and command tumor cell activities, including proliferation, migration, and apoptosis.28, 29, 30 Based on these mechanisms, we speculated that elevated PFC might contribute to hematogenous metastasis of tumor cell.