Mutations in the TP63 gene have been associated with seven diseases: Ectodermal dysplasia–Ectrodactyly Cleft lip/palate syndrome 3 (EEC3, OMIM #604292), Ankyloblepharon‐Ectodermal defects‐Cleft lip/palate syndrome (AEC, OMIM #106260), Rapp‐Hodgkin syndrome (RHS, OMIM 129400), Limb Mammary syndrome (LMS, OMIM #603543), Acro‐Dermato‐Ungual‐Lacrimal‐Tooth syndrome (ADULT, OMIM #103285), Split‐Hand/Foot Malformation type 4 (SHFM4, OMIM #605289) and Isolated cleft lip/cleft palate (orofacial cleft 8, OMIM #129400). The gene discussed is TP63; the disease is limb-mammary syndrome.