Recent studies have found that the development of AD is closely correlated with mitochondrial autophagy defects.153, 154 In a transgenic mouse model of AD, the amyloid‐β protein is accumulated, accompanied by a cascade of upregulated mRNA levels of mitochondrial autophagy‐associated proteins, such as p62, PARK2, DNM1L, BECN1, BNIP3, PINK1, and LC3. This evidence concerns the gene SQSTM1 and Alzheimer disease.