PRKN and Parkinson disease: Mitochondrial dysregulation can lead to PD.8, 9, 10, 11 Mutations in PINK1 and Parkin genes are associated with autosomal recessive early‐onset PD.12, 13PINK1 and Parkin genes exert synergistic effect on mitochondrial maintenance‐related functions, such as mitochondrial motility, proteasomal degradation of mitochondrial proteins, and mitophagy.