Inhibiting the α‐tubulin deacetylase HDAC6 is also considered a potential avenue for treating HD, but the mechanism remains unclear, and studies suggest that HDAC6 may block mitophagy.174 Various studies have revealed reduced mitophagy in the brain of HD patients, which lead to subsequent dysfunction.171 Currently, developing treatment strategies for HD by rebuilding stable mitophagy balance has attracted great interests. This evidence concerns the gene HDAC6 and Huntington disease.