In the Drosophila model of HD, increased PINK1 expression can suppress the mitochondrial morphological abnormalities and accumulation, while overexpression of PINK1 reduces neuronal vacuolization, restores ATP levels, and reduces mortality in adult Drosophila. These results suggest that PINK1 can protect neurons against mutant Htt toxicity. Here, PINK1 is linked to Huntington disease.