LRRK2 and Parkinson disease: Endogenous LRRK2 can interact with the regulators of mitochondrial fission and fusion (such as Drp1, OPA1, and Mfn).142 In PD patient fibroblasts with LRRK2 G2019S mutation, there is increased susceptibility to MPP+‐induced cellular death.143 The loss of LRRK2 will disrupt the autophagy pathway and promote the production of autophagosomes.144, 145 Although CMA may mediate the degradation of LRRK2, but the high levels of wild‐type LRRK2 will obstruct the translocation of the CMA complex, leading to the deficiency of CMA.146, 147