The current results only partially reveal the role of mitophagy mediated by the PINK1/Parkin pathway in PD, while there are few studies on AD and HD, and many questions have not been clarified.193, 194 NIX/BNIP3L and FUNDC1 mainly regulate mitochondrial autophagy under hypoxic conditions, but the regulation of mitochondrial autophagy under hypoxic and ischemic conditions needs to be further explored.195. This evidence concerns the gene PRKN and Alzheimer disease.