PRKN and Parkinson disease: The current results only partially reveal the role of mitophagy mediated by the PINK1/Parkin pathway in PD, while there are few studies on AD and HD, and many questions have not been clarified.193, 194 NIX/BNIP3L and FUNDC1 mainly regulate mitochondrial autophagy under hypoxic conditions, but the regulation of mitochondrial autophagy under hypoxic and ischemic conditions needs to be further explored.195