In addition, α‐Syn can activate mPTP through interacting with the voltage‐dependent anion channel (VDAC) or adenine nucleotide translocator (ANT).127 A53T mutant of α‐Syn can reside in the mitochondrial membrane and impair mitochondrial function as the monomers and oligomers.128 Importantly, α‐Syn can be removed through mitochondrial fission and the activity of Parkin,129, 130 and its role in activating the autophagy of polarized mitochondria demonstrates that there exists certain link between Parkin and α‐Syn during mitophagy in PD pathogenesis. Here, PRKN is linked to Parkinson disease.