Several known lncRNAs (HOTAIR, GAS5, and UCA1) have recently been reported to be differentially expressed in EEC tissues and involved in EEC progression and metastasis.32, 33 In this study, the analysis of 30 EEC samples revealed that lncRNA Lnc‐NA is significantly down‐regulated in EEC tissues compared with normal or benign tissues. This evidence concerns the gene HOTAIR and exstrophy-epispadias complex.