TNFSF10 and neoplasm: Although NR4A1 target genes are poorly characterized, the proapoptotic effects of NR4A1 may be achieved by its transactivation function of acting as a transcription factor (TF) for apoptosis‐inducing genes.38, 39, 40, 41 Consequently, proteins in the extrinsic and intrinsic apoptosis pathways, including TRAIL, Puma, and all isoforms of Bim, have already been identified as potential targets of NR4A1 in an NR4A1 transgenic mouse model.42, 43 These results indicate that NR4A1 plays an important role in tumour apoptotic signalling.