GATA3 and chronic kidney disease: Genetic evaluation for familial CKD using WES in the proband identified a novel GATA3 missense variant (GATA Binding Protein 3 transcription factor), which leads to substitution of a highly conserved amino acid residue (GATA3: NM_002051: cC703A:pP235T) predicted to be deleterious by bioinformatics scores.