CD8A and neoplasm: Consistently, the mRNA expression of cytotoxic effector cytokine IFN-γ, produced by functionally active CD8+ T and NK cells, was higher in the therapy-applied Oasl1−/− lungs, and more apoptotic nonhematopoietic cells (that are thought to be mainly tumor cells) [28, 29] were observed in the therapy-applied lungs of Oasl1−/− mice compared to untreated Oasl1−/− mice.