The observation that CD8+ T and NK cells (cytotoxic effector cells), as well as CD8α+ DCs (major cells cross-presenting tumor antigen to CD8+ T cells) [27], were present in a much higher proportion, yet the proportion of MDSCs and Treg (immunosuppressive cells) within CD45+ cells were lower or unchanged relative to untreated Oasl1−/− mice, indicates that more effective tumor antigen cross-presentation and cytotoxic CD8+ T cell production occur in the lungs of cisplatin-treated Oasl1−/− mice. The gene discussed is PTPRC; the disease is neoplasm.