Previously, we have shown that IFN-I-inducible 2′-5′ oligoadenylate synthetase-like 1 (OASL1), a specific inhibitor of IRF7 (master transcription factor (TF) for IFN-I) translation, negatively regulates IFN-I production upon tumor challenge, similar to those of viral infections [19–22]. Here, OASL is linked to neoplasm.