We also found that the therapy-applied Oasl1−/− mice contained more cytotoxic effector cells, such as CD8+ T cells and NK cells, and produced more cytotoxic effector cytokine IFN-γ as well as IFN-I in their tumor-containing lungs compared to untreated Oasl1−/− mice. The gene discussed is OASL; the disease is neoplasm.