The top 10 Canonical Pathways were assigned to Ceramide Signaling, Sphingosine-1-phosphate Signaling, Sphingomyelin Metabolism, Sphingosine and Sphingosine-1-phosphate Metabolism, RhoA Signaling, Gα12/13 Signaling, Human Embryonic Stem Cell Pluripotency, eNOS Signaling, Primary Immunodeficiency Signaling, and Lipid Antigen Presentation by CD1. The gene discussed is CD1B; the disease is inborn error of immunity.