Donepezil and all the broccoli samples lowered the Bax/Bcl2 ration while only the broccoli samples lowered the expression of cleaved caspase-3 suggesting that the broccoli sample, especially SB-Enz-PEF, possesses higher potency to increase cell survival and decrease neuronal death in the dementia model like scopolamine treatment. Here, BAX is linked to dementia.