However, several studies suggested that ketosis-onset diabetes was characterized as higher age of onset, overweight, the family history of diabetes, discontinuation of insulin treatment after euglycemic remission, and a variable response to diet and oral hypoglycemic agents, which supported that ketosis-onset diabetes was more likely to be a sub-group of type 2 diabetes [2, 4]. Here, INS is linked to type 2 diabetes mellitus.