Many target genes such as transcription factors of pluripotency (Oct-4, Sox-2, Nanog, and c-Myc) or epithelial-mesenchymal transition (EMT) genes (MMP-9, CXCR4, Snail-1, and N-cad) are upregulated via Shh stimulation, resulting in high metastatic phenotype and drug resistance or tumor relapse as well [11, 12]. This evidence concerns the gene SHH and neoplasm.