In this study, we found that AKT3 activity was suppressed but AMPK was activated in both lung tissue and skeletal muscle tissue of mice with BLM-induced lung fibrosis, which indicates that lung tissue and muscle tissue cells were affected by circulating cytokines during lung fibrosis to mediate muscle mass through the activation of the FOXO transcription factor. The gene discussed is AKT3; the disease is pulmonary fibrosis.