In addition, both cytokines can also induce the expression of Atrogin-1 and MuRF1, suggesting that BLM-induced lung fibrosis in mice may influence the proteolysis of long-distance muscle tissues through the circulation of both IL-6 and IL-33 secreted from injured lungs during lung fibrosis (Figure 6(b)). Here, IL33 is linked to pulmonary fibrosis.