NFKB1 and bacterial infectious disease: Among them, these bacteria can induce NF-κB-mediated responses, promote cell survival, activate oncogenic pathways, reduce proapoptotic proteins expression, increase cell migration and invasion, increase the expression of EMT-associated proteins, enhance metastasis, etc. In spite of this knowledge, more studies are needed to elucidate the mechanisms triggered by other periodontal bacteria and also understand the tumorigenic effect of combined bacterial infections.