In this model, F. nucleatum generates a proinflammatory microenvironment associated with an NF-κB-mediated response (COX-2, IL-1β, IL-6, IL-8, IL-10, and TNF-α) [167], which provides a critical link between inflammation and cancer [168] and is implicated in potentiating colorectal tumorigenesis in mice [167, 169]. Here, NFKB1 is linked to cancer.