The 4-week streptozotocin treatment did not alter the body weight of wt and Trpv4-/- mice (19.4 ± 0.4 g; n = 11 vs. 18.3 ± 0.5 g; n = 9; P > 0.05), but it induced hyperglycemia at similar levels (P > 0.05) in both groups (412.5 ± 22.9 mg/dl; n = 11 vs. 499.7 ± 4.7 mg/dl; n = 9, S1 Fig). The gene discussed is TRPV4; the disease is Hyperglycemia.