ZFP36L2 is a member of an RNA-binding protein family and exhibits opposing roles in different tumor types, playing an oncogenic role in pancreatic cancer12, but displaying tumor-suppressor activity in esophageal squamous-cell carcinoma (ESCC)13; however, the biological relevance of ZFP36L2 in GC remains unknown. This evidence concerns the gene ZFP36L2 and esophageal squamous cell carcinoma.