MYC and cancer: Gene set enrichment analysis (GSEA) further supported our genomic WES based findings, as the gene expression signature of NPM1mut loss relapse samples showed an enrichment of genes belonging to Pathways in cancer and more specifically of MAPK and WNT signaling, while in diagnosis samples pathways related to cell cycle and MYC signaling were affected (Fig. 5b, c and Supplementary Data 5).