This model was established by i.v. injection of 4T1 cancer cells expressing firefly luciferase (fLuc-4T1) into unilateral orthotopic tumour-bearing mice before the primary tumours were eliminated by HMME/R837@Lip-augmented SDT and enhanced immunotherapy deriving from R837 and anti-PD-L1 blockade. The gene discussed is CD274; the disease is cancer.