In addition, the variations of cytokines (e.g., TNF-a, IL-6, and IL-12p70) in the serum of the 4T1-tumour-bearing mice after treatment indicated that although both HMME/R837@Lip (−) and HMME@Lip ( + ) increased secretion of the proinflammatory cytokines, the secretions induced by HMME/R837@Lip ( + ) were much higher, which were favourable for triggering the antitumour immunological responses. Here, TNF is linked to neoplasm.