Of the insulin-resistant subjects with lipodystrophy, 13 had partial forms [8 subjects with familial partial lipodystrophy (FPLD) type 2 due to LMNA mutations, 5 subjects with FPLD3 due to PPARG mutations), and 3 had generalized lipodystrophy [2 subjects with acquired generalized lipodystrophy (AGLD) and 1 due to mutations in the PCYT1A gene (28)]. The gene discussed is INS; the disease is familial partial lipodystrophy.