FOXO1 and diabetic cardiomyopathy: FOXO1 is also known as forkhead within the rhabdomyosarcoma, as well as a transcription factor playing an important role in regulation of gluconeogenesis.28, 29 In VSMCs, FOXO1 has been powerfully proven to regulate vascular remodeling and diabetic cardiomyopathy.30, 31 In addition, FOXO1 functions a transcription factor to modulate the human cancers.32