These findings provide a rationale for clinical studies aiming to reduce elevated Lp(a) and OxPL levels in patients with aortic stenosis as a means of slowing disease progression and delaying the need for AVR.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: Elevated blood levels of Lp(a) and OxPL-apoB are associated with accelerated valve calcification and hemodynamic progression of aortic stenosis. This evidence concerns the gene LPA and aortic stenosis.