This same tumor also had six variants of uncertain significance: ARID2 c.1672C > T p.(R558C), FLT3 c.2546G > A p.(R849H), IGF1R c.3897C > G p.(N1298K), MSH6 c.1157C > G p.(P386R), PBRM1 c.2504G > A p.(R850H), and RNF43 c.1114C > T p.(P372S). The gene discussed is RNF43; the disease is neoplasm.