ACSS2 and bacterial infectious disease with sepsis: About 65% of the ducks infected with the mutants FY26Δacs and FY26Δacs-yjcH-actP presented bacteremia symptoms compared to the ducks challenged by wild-type FY26, suggesting that the loss of acs-yjcH-actP operon might impair APEC capability to pass through the immune defense of duck lung tissues into the bloodstream (P < 0.01).