EIF2A and ovarian carcinoma: In a separate work, we have shown that culturing ovarian cancer cells in complete medium containing RV or in EBSS inhibited protein synthesis, as indicated by down-phosphorylation of mTOR and of its downstream target eIF4E-binding protein 1 (4E-BP1) and of S6 and concomitant hyper-phosphorylation of eIF2α, while inducing autophagy in parallel [51].