We suggest that autoantibodies to a panel of mitochondrial antibodies including MNRR1, together with positive IHC staining for this protein, and perhaps for other nDNA- and mtDNA-encoded mitochondrial antigens, on breast biopsies performed routinely on women having a BIRADS4 assessment might indicate that the subject is at a higher risk for BC than is suggested by a BBD diagnosis found at breast biopsy. The gene discussed is CHCHD2; the disease is breast cancer.