However, it is clear that MNRR1 is not the only mitochondrial protein involved in breast carcinogenesis since we found autoreactivity to a number of mtDNA- and nDNA-encoded mitochondrial proteins in BC sera (Tables 1 and 2) that suggest the widespread autoreactivity to mitochondrial antigens is the expression of autoimmunity in BC. This evidence concerns the gene CHCHD2 and Autoimmunity.