For example, Novel Ras Effector 1 (NORE1) is a gene that is localized on 1q32.1, and NORE1 and RASSF1A form homo and hetero dimers by associating with Ras-like GTPases, which may be important for its function as a suppressor gene of PNET [12, 16, 17]. The gene discussed is RASSF1; the disease is primitive neuroectodermal tumor.