CD274 and neoplasm: Treatment of selected patients (PD-L1 expression on at least 50% of the tumor-cells, no EGF-receptor mutation or ALK-translocation) with a monoclonal humanized antibody against PD-1 (Pembrolizumab, KEYTRUDA©) correlated with an increased progression-free survival (median 10.3 months vs. 6.0 months, p < 0.001) and an overall survival of 80.2% at 6 months compared to 72.4% in patients receiving standard chemotherapy (p < 0.005).