Specifically, parameters that have been reported to be independent prognostic factors in HCC include bilirubin [15, 16], albumin [16], international normalized ratio (INR) [17], alkaline phosphatase (ALP) [18], Child-Pugh classification [19, 20], albumin-bilirubin (ALBI) grade [21, 22], Model for End-stage Liver Disease (MELD) [23], ALP-to-platelet ratio [24] and albumin-to-ALP ratio [17, 18, 25]. This evidence concerns the gene ALB and End Stage Liver Disease.