The carbohydrate antigen 125 (CA125) was first evaluated in the early 1980s, but this marker has low sensitivity in the early stages of ovarian cancer.[12–14] The study conducted by Yanaranop et al[15,16] in 2017 indicated that the specificity of Human Epididymis Protein 4 (HE4) was 86%, and the AUC of HE4 (0.893) was higher than CA125 (0.865). Here, WFDC2 is linked to ovarian cancer.