DUOX2 and cyclic hematopoiesis: Three DUOX2 single nucleotide polymorphisms (SNPs)—p.P138L (rs2001616), p.L1067S (rs269868), and p.H678R (rs57659670)—have variably demonstrated enrichment in CH cases, although conflicting functional characterization and prevalence data have led to ambiguity regarding their significance (12,16,17).