The same group of authors immunohistochemically analyzed the tissue and RCs of Leydig cell tumors, testicular adrenal rest tumors, testicular tumors of adrenogenital syndrome, and cases of androgen insensitivity syndrome, demonstrating that RCs represent crystallized forms of a 3BHSD/calretinin complex (30). The gene discussed is CALB2; the disease is neoplasm of testis.