LZTR1 and Noonan syndrome: Recently, Steklov et al used a Lztr1 deletion mouse model and found that Lztr1 haploinsufficiency in mice recapitulates some of the Noonan syndrome phenotype that is, facial dysmorphism and heart malformation, whereas loss in Schwann cells drives dedifferentiation and proliferation (Steklov et al., 2018).