IL17RB and breast cancer: For example, increased expression of IL‐17RB (IL‐25 receptor) was strongly correlated with poor prognosis in breast cancer patients, and blocking IL‐17B‐IL‐17RB signaling with an anti‐IL‐17RB antibody resulted in reducing metastasis in pancreatic cancer by silencing NF‐κB‐mediated multiple chemokines release.15, 16 Therefore, the different functions of IL‐25 in different cells remain to be further revealed.