This investigation into the potential molecular mechanisms underlying VAD‐induced CS demonstrated dynamic changes in the expression of the SULT1C2A‐rno‐miR‐466c‐5p‐Foxo4 axis in VAD‐induced CS, suggesting that this specific axis contributes to the pathogenesis of VAD‐induced CS. The gene discussed is FOXO4; the disease is Cowden syndrome 1.