Specifically, lncAIS impacts the function of NF90 and HOXD8 and hinders RUNX2 transcription.18 Previously, we performed sequencing data analysis to build ceRNA networks in embryonic tissues of rats with VAD‐induced CS and found that, based on Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, a SULT1C2A‐rno‐miR‐466c‐5p‐Foxo4 axis as well as the Phosphoinositide 3 kinases (PI3K)‐AKT pathway appear to be involved in CS pathogenesis based on bioinformatics prediction and sequence analysis.19 This evidence concerns the gene HOXD8 and Cowden syndrome 1.