It is widely known that macrophage IL‐6, being a major target gene for p65, can cause tumour growth, which made us wonder if p65 was also involved in the Six1‐mediated induction of IL‐6 expression in macrophages.24, 25 To address this, we initially examined the influence of macrophage Six1 expression on p65 protein expression. This evidence concerns the gene SIX1 and neoplasm.