TNF and melanoma: However, HPSE expression can be induced in a number of inflammation related pathological processes by mediators such as tumour necrosis factor (TNF) or interleukin 1β (IL‐1β).27, 28, 29 In this study, we screened breast cancer T47D cells, melanoma MDA‐MB‐435s cells and MV3 cells for heparanase expression.