Nevertheless, we were able to obtain reproducible up‐regulation of genes including EGR1, TXNIP, AXL, CYR61, LIMS2 and TNFRSF12A in MDA‐MB‐435s and MV3 melanoma cell lines and significant increase in protein levels as well (Figure S2D,E), suggesting potential implication in other melanoma cells. The gene discussed is CCN1; the disease is melanoma.