HPSE and neoplasm: Numerous clinical studies have consistently demonstrated that up‐regulation of HPSE expression correlates with increased tumour size, tumour angiogenesis, enhanced metastasis and poor prognosis.12, 13, 14 In contrast, silencing of HPSE or treatments of tumour‐bearing mice with heparanase inhibiting compounds, markedly attenuate tumour progression.15, 16, 17, 18 However, the mechanisms underlying these effects remain to be further investigated.