Indeed, an in vivo study showed that low dosage exposure to Dex increases autophagy in cortical mouse bone, and this increase is well correlated with antioxidant gene expression.8 In contrast to our observation in osteocytes, impairment of autophagy via ATG5 knockdown instead decreases basal as well as drug‐induced oxidative stress in osteosarcoma cells.23 As discussed above, autophagy possesses a biphasic role: Either total impairment or overenhancement of autophagy may exert adverse effects on cells. The gene discussed is ATG5; the disease is osteosarcoma.